Pharmaceuticals and Biologics

Need a solution to improve the production capacity of pharmaceuticals and biologics without sacrificing yield in large-scale production? PolarDry® electrostatic drying revolutionizes the production of oligonucleotide and peptide therapeutics and pharmaceuticals. Avoid the inherent limitations of traditional drying processes like freeze drying / lyophilization and conventional spray drying that limit production with PolarDry®.

Common Challenges

Test and Refine Active Ingredient or Product

Working to validate or refine a formula? Our labs provide us with the ability to test and prove processes using PolarDry. This can bring you greater success, months faster and with less risk.

Develop a Production Process Pilot

Ready to move from bench-scale processing to pilot production? Using the right PolarDry model and tapping our experience can help you achieve a successful pilot production process.

Scale Up a Production Process

Time to produce at scale? We can help you develop a business case for your innovation and help you equip and set up full-scale production at your plant.

PolarDry® electrostatic drying technology offers a solution to improve the production capacity of pharmaceuticals and biologics without sacrificing yield in large-scale production. Electrostatic drying enables continuous and faster drying at moderate temperatures with high yields and produces powders with desired powder properties while maintaining the purity of active components when compared to freeze drying and convention spray drying. PolarDry® eliminates drying at extremely low temperatures and post processing of powders during freeze-drying and also avoids the drastic loss of yield caused by the loss of purity and activity of active components caused by high temperature used in conventional spray drying.

Applications

Peptides and proteins
Oligonucleotides
Cell and gene therapy products
Inhalables and injectables
Thermosensitive active pharmaceutical ingredients
Small molecules
Microbiome therapeutics

PolarDry® Electrostatic Drying

Process benefits

Low operating temperature allows for efficient drying of heat-sensitive materials
Gentler drying for thermosensitive materials
Faster processing to match supply with demand
Modular design to fit into your continuous manufacturing or batch production line
Save processing time by eliminating evaporation and concentration steps

Available for both aqueous and solvent applications
Nitrogen-inerted
Complete product line is scalable, from R&D to production-size models
Contained, robust processing
Inner liner in production scale models makes for easy clean-up/changeover
Process products with low glass transition temperature (Tg)
Recirculation of drying gases in production-scale models
Substantially shorter process time than lyophilization and eliminates post processing for particle size modification

Product Benefits:

Superior morphology
No oxidation
Superior flowability
Lower heat degradation of molecules/components
Lower retention of harmful solvents in final dried powder
Lower drying temperatures prevents reactions and formation of impurities

Schedule an exploratory call Contact Us